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Changing Drug Regimen Boosts Survival in Metastatic Breast Cancer

July 31, 2012

By Loyola University Health System

A study co-authored by a Loyola researcher and published in the New England Journal of Medicine is offering new hope to women with advanced breast cancer.

The study found that combing two drugs that normally are each given as single agents significantly extended the lives of women with metastatic breast cancer. Kathy Albain, MD, a breast cancer specialist at Loyola University Medical Center, is among the main authors of the study.

 

Researchers find driver of breast cancer stem cell metastasis

July 26, 2012

Researchers at the University of Michigan Comprehensive Cancer Center have found that a cancer gene linked to aggressive spread of the disease promotes breast cancer stem cells. The finding implies a new way to target the behavior of these lethal cells. The finding involves the cancer gene RhoC, which has previously been shown to promote metastasis of many types of cancer. RhoC levels increase as breast cancer progresses and high levels of RhoC are associated with worse patient survival.

 

Metastatic Breast Cancer Cells Diminish Body’s Immune Response

July 26, 2012

By Anna Azvolinsky, PhD

Scientists in Australia have found that metastatic breast cancer cells suppress an immunologic pathway. Belinda S. Parker of the Peter MacCallum Cancer Centre in Melbourne and colleagues show that administering interferon (IFN) can reduce bone metastases and increase the survival time in a metastatic breast cancer mouse model.

 

Gathering Place abruptly removes breast cancer patient photo exhibit, says it stirred emotions

July 20, 2012

By Angela Townsend, The Plain Dealer

CLEVELAND, Ohio -- On July 13, Angelo Merendino presided over the first night of what was supposed to be a 10-week-long photography exhibit at The Gathering Place in Westlake. A standing-room-only crowd of a few hundred people gathered at the cancer support center for a look at more than 50 stark black-and-white images Merendino took that chronicled his late wife Jennifer's experience as a breast cancer patient.

On Thursday, just six days later, The Gathering Place took the exhibit down.

F.D.A. Approves Drugs for Cancer and Myeloma

July 20, 2012

By Andrew Pollack

New drugs for breast cancer and multiple myeloma won approval from the Food and Drug Administration on Friday, expanding options for patients in advanced stages of those diseases.  

Philadelphia-Based Non-Profit Poised to Fill Gap

July 18, 2012

Living Beyond Breast Cancer (LBBC), a national 501(c)(3) organization based in suburban Philadelphia, is preparing its staff and volunteers to address the needs of women diagnosed with breast cancer who may find themselves without resources due to the recent closing of Y-ME.

 

Breast cancer metastasis to bone driven by stress, researchers report

July 17, 2012

By Anne Seccombe

Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered.

The studies, reported July 17 in PLoS Biology, demonstrate in mice that activation of the sympathetic nervous system - the "fight-or-flight" response to stress - primes the bone environment for breast cancer cell metastasis. The researchers were able to prevent breast cancer cell lesions in bone using propranolol, a cardiovascular medicine that inhibits sympathetic nervous system signals.

 

Avastin Doesn't Benefit Breast Cancer Patients, Study Confirms

July 14, 2012

By Susan E. Matthews, MyHealthNewsDaily Staff Writer

The drug Avastin neither prolongs the lives of breast cancer patients nor improves their quality of life, a new review of several randomized control trials of the drug confirms.

 

Brain Metastasis in Breast Cancer: Last Barrier to the Cure?

July 13, 2012

By Shaheenah Dawood, MRCP(UK), MPH, Massimo Cristofanilli, MD

The last two decades have seen the development of a variety of novel therapeutic agents that have improved prognoses for women with breast cancer. Certainly for women with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, the introduction of trastuzumab(Drug information on trastuzumab) (Herceptin) has altered the natural history of the disease, turning a once aggressive cancer into one with a favorable prognosis.[1] Moreover, our understanding of the biology of breast cancer has also grown; we have realized that it is not a homogeneous disease but rather a heterogeneous one composed of a number of subtypes, each with its own unique natural history and survival outcomes.[2] Despite such advances, however, a diagnosis of brain metastases in a woman with breast cancer still connotes a debilitating and incurable condition...

Tumor Biology Trumps Anatomy in Breast Cancer Brain Metastases

July 13, 2012

By Mark D. Pegram, MD

In this issue of ONCOLOGY, Drs. Lim and Lin present a comprehensive and up-to-date review of the basic biology of breast cancer brain metastasis (BCBM) and of emerging strategies for treating this increasingly common complication of advanced breast cancer (BC) (BC is second only to non-small-cell lung cancer in the frequency of central nervous system [CNS] metastasis.) It is clear that as the efficacy of treatments for extracranial metastatic BC have improved over time, CNS metastases have increasingly been exposed as a vulnerability, with the CNS indeed a sanctuary site; they necessitate directed (often multidisciplinary) therapeutic approaches requiring special expertise (ideally via an experienced interdisciplinary team).

 

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