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Update on Novel Drug Targets in Metastatic Breast Cancer

May 16, 2014

By Onc Live: Massimo Cristofanilli, MD, FACP

Metastatic breast cancer (MBC) is a fatal disease involving the expansion of cancerous cells from the breast to other areas of the body. Treatments for MBC are often limited to palliative care; as a result of MBC is usually fatal.

As research continues, factors such as age at diagnosis, hormone receptor (HR) status, human epidermal growth factor receptor 2 (HER2) overexpression/amplification, and site of metastases are currently used to stratify patients into groups with different prognoses and to predict response to systemic treatments.

The STAR treatment: South Jordan woman fighting cancer in unique ways

May 15, 2014

By Wendy Leonard, Utah Deseret News

SOUTH JORDAN — Michelle Thompson is knee-deep into stage 4 cancer, but you wouldn't know it from looking at her.

Her silver-blonde hair and sparkling blue eyes are just as bright as they were prior to the presumably devastating diagnosis in early 2013.

"I have this cancer that is supposed to mean a long, slow decline, but, all of a sudden, I'm feeling better," Thompson said. "I am reversing a no-reversible trend, and that sort of thing makes you happy."

It helps, too, that she's pushing herself to be better every day, including employing a newly FDA-approved procedure that eliminates her most hearty source of pain — tumors that dot her radiation-plagued broken spine.

Approximately 1.5 million Americans are diagnosed with cancer every year, and two-thirds will develop bone metastasis, with the spine being the most common site, according to the International Journal of Surgical Oncology. The painful spine tumors are particularly prevalent in breast cancer patients, like Thompson.

Guarded optimism on new breast cancer drug (CDK 4/6 Inhibitors and ER+ disease)

April 6, 2014

By Andrew Pollack, NY Times

SAN DIEGO — Researchers say that a new type of drug can help prevent advanced breast cancer from worsening, potentially providing an important new treatment option for women and a blockbuster product for Pfizer.

In a clinical trial, the drug cut in half the risk that cancer would worsen, or progress, researchers said here on Sunday. The median time before the disease progressed or the women died was 20.2 months for those who received the drug, compared with 10.2 months for the control group.

Ludwig researchers to give plenary talks on immunotherapy (CD47) at 2014 AACR Annual Meeting

April 6, 2014

By Ludwig Cancer Research press release

April 6, 2014, San Diego, Calif. - Ludwig researchers Irving Weissman and Jedd Wolchok will each give a talk during tomorrow’s plenary session of the AACR Annual Meeting 2014, starting at 8:45 am PT. The session, dedicated to one of the most promising and rapidly advancing areas of cancer research and therapy, is titled Targeted Immunotherapy: Mobilizing the Immune System against Cancer.

Weissman, who directs the Ludwig Center at Stanford, will speak about his team’s characterization of a cell-surface protein that is found on almost every major kind of cancer cell and their work describing its role in protecting malignant tissue. They have shown that cancer cells use this protein, CD47, to transmit a “don’t eat me” signal to patrolling immune cells known as macrophages, which would otherwise kill and ingest them to initiate a devastating immune attack on tumors.

ASCO Special Article in JCO Encourages Researchers, Industry to Achieve More Meaningful Results

March 20, 2014

By ASCO.org

ASCO is urging cancer researchers, clinical trial sponsors, and drug developers to employ clinical trial designs that aim to significantly extend the lives of people with cancer. 

In a Special Article published today in the Journal of Clinical Oncology, ASCO outlines overall survival goals for cancer clinical trials in several diseases that researchers should aim for—and patients should expect. The recommendations, developed by the ASCO Cancer Research Committee working with other experts and cancer patient advocates, provide examples of "clinically meaningful outcomes" in four types of cancer: advanced pancreatic, lung, breast, and colon cancers.

Emerging Trends in Treating Her2+ Metastatic Breast Cancer

March 8, 2014

By Onc Live: Dr. Kimberly Blackwell

Since its approval in 1998 to treat metastatic breast cancer, the anti-HER2 monoclonal antibody trastuzumab has dramatically expanded life expectancy and improved quality of life for women diagnosed with HER2-positive disease. It remains the standard-of-care, first-line treatment for metastatic breast cancer. In less than a decade, the FDA has added three new drugs to the arsenal to treat advanced HER2-positive disease, while a growing number of clinical studies are evaluating dual-agent approaches to therapy through a variety of drug combinations. - See more at: http://www.onclive.com/conference-coverage/mbcc-2014/Blackwell-Explores-Emerging-Trends-in-Treating-HER2-Metastatic-BC#sthash.bEsUvLip.dpuf

Genes, Drugs & Breast Cancer : Dr. Matthew Ellis at TEDxStLouis

January 17, 2014

By TED talk: Dr. Matthew Ellis

Dr. Matthew Ellis of the Siteman Cancer Center shares recent advances in the on-going fight against breast cancer including PDX modeling in this TED talk.

Twitter Responds: Reactions to Patients Tweeting about Their Cancer

January 14, 2014

By ASCO ConnectionL Dr. Don Dizon

On one afternoon last week, I sat at my desk working on a paper when my iPhone buzzed, telling me I had a new message. This message, forwarded from my Twitter account, alerted me to an editorial published in the Guardian (which has since been removed because it was “inconsistent with the Guardian editorial code). Entitled “Forget funeral selfies. What are the ethics of tweeting a terminal illness?,” it was written by Emma Keller and used the tweets of Lisa Bonchek Adams (@AdamsLisa), a woman living with metastatic breast cancer, who has been actively engaged on social media (even before her diagnosis of metastatic disease), including writing her own blog and tweeting actively. She has been hospitalized and has blogged and tweeted about her experience as an inpatient.

MBCN responds: Bill Keller's Misguided NYTimes Op-Ed piece

January 13, 2014

By MBCNbuzz blog

Bill Keller’s op-ed piece on “Heroic Measures”  (January 12, 2014)  contains egregious factual errors. It also misrepresents what metastatic breast cancer is and how it is treated.

Whatever it takes

January 9, 2014

By Cure Today Guest Blogger

Do whatever it takes to keep going.

And that includes ignoring guilt about not being the perfect parent and nasty looks from people who think such a creature exists. As a wife and mom living with cancer, I have started applying the whatever it takes theory to other areas of my life as well. While a "normal person" might say he/she has a lot on their plate, some of us have plates the size of a turkey platter. My day to day can be pretty heavy, so I give myself a pass on the little things like laundry to fold or dishes to wash.

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