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Breast Cancer Cocktail Buys More Than a Year of Life

February 24, 2015

By Maggie Fox and Maren Shapiro

A cocktail of three breast cancer drugs buys patients an extra 16 months of life — a good news story so unusual, doctors have rushed to make it standard therapy, researchers said Wednesday.

Iterative and prolonged remission in metastatic breast cancer using pegylated irinotecan

February 13, 2015

By Journal of Medical Case Reports 2015, 9:5

Pegylated irinotecan NKTR-102 is a topoisomerase I inhibitor-polymer conjugate. This new formulation of irinotecan has been evaluated in a phase II clinical trial and is showing remarkable activity.

New York Attorney General Targets Supplements at Major Retailers

February 5, 2015

By New York Times

GNC, Target, Walgreens and Walmart were accused of selling fraudulent and potentially dangerous herbal supplements and told by New York State officials to stop selling them.

FDA Approves Ibrance for Postmenopausal Women with Advanced Breast Cancer

February 4, 2015

By FDA News Release

The U.S. Food and Drug Administration today granted accelerated approval to Ibrance (palbociclib) to treat advanced (metastatic) breast cancer.

World Cancer Day February 4

February 4, 2015

Taking place under the tagline ‘Not beyond us’, World Cancer Day 2015 will take a positive and proactive approach to the fight against cancer, highlighting that solutions do exist across the continuum of cancer, and that they are within our reach.

Second-Line Everolimus in Metastatic Breast Cancer

February 2, 2015

By Onc Live

Several second-line treatment options exist for patients with ER-positive metastatic breast cancer following progression on frontline therapy.  Also 12 videos with outstanding MBC oncologists about new treatments.

Cancer Drugs Fund: Life-extending drugs to be denied to NHS patients in England as fund overspends

January 19, 2015

By The Independent, Charlie Cooper

Sixteen life-extending cancer drugs will no longer be available to patients in England from March after the NHS announced it would not pay for them through the Government’s flagship Cancer Drugs Fund (CDF).

The drugs have been removed from a list of treatments paid for by the CDF in a bid to cut costs. The £280m fund was due to overspend by £100m in 2014-15.

Panel Laments Lack of Options for Advanced Breast Ca

November 17, 2014

By Medpage Today, Charles Bankhead

The lack of options for advanced breast cancer has created a sense of urgency for high-quality research and clinical trials to address a multitude of unanswered questions, a guideline panel concluded.

Though treatment advances have extended the duration of survival, advanced breast cancer remains almost uniformly fatal. Consequently, the principal goals have been to improve the length and quality of life for patients.

Non-publication of large randomized clinical trials: cross sectional analysis

November 1, 2014

By The BMJ (British Medical Journal), Christopher W. Jones, MD


Randomized clinical trials are a critical means of advancing medical knowledge. Clinical trials depend on the willingness of participants to expose themselves to the risks of randomization, blinding, and unproven interventions. The ethical justification for these risks is that society will eventually benefit from the knowledge gained from the trial.1 Because the risks involved in trial participation may be significant, and because individual trial participants often do not benefit directly from trial participation, substantial safeguards have been implemented to protect the interests of study participants both prior to and during the trial.2 These safeguards take multiple forms, including oversight by institutional review boards, the informed consent process, and data and safety monitoring boards. Until recently, the protection of the interests of study participants after trial completion has received significantly less emphasis. This began to change in 1997 with the signing of the Food and Drug Administration Modernization Act in the United States, which mandated that the US Department of Health and Human Services establish a registry of clinical trials, thereby providing permanent, public access to information on the conduct of both publicly and privately funded clinical trials.3

Pfizer's palbociclib on track for early 2015 launch

October 15, 2014

By PM Live

Pfizer will get a rapid review at the US FDA for its new breast cancer candidate palbociclib, meaning it could be approved in the first quarter of 2015.

The FDA has said it will deliver a verdict on palbociclib - one of the most anticipated drugs in Pfizer's pipeline with peak sales potential of $3bn-$4bn according to analysts - by April 13 next year.

Pfizer is seeking approval of palbociclib in combination with Novartis' Femara (letrozole) as a first-line treatment for postmenopausal women with oestrogen receptor positive (ER+), HER2-negative advanced breast cancer who have not received previous systemic treatment.

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