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Breakthrough Designation Granted to Entinostat for Advanced Breast Cancer

September 11, 2013

By OncLive

The novel HDAC inhibitor entinostat in combination with exemestane has received a Breakthrough Therapy designation from the FDA for its potential to reverse resistance to hormonal therapies used to treat patients with advanced estrogen receptor (ER)-positive breast cancer.

Managing Bone Health in Metastatic Breast Cancer

September 6, 2013

By OncLive

Two agents, denosumab (Xgeva) and zoledronic acid (Zometa), are currently approved to help reduce the incidence of skeletal-related events (SREs) in patients with metastatic breast cancer (MBC).

Aggressive breast cancer may be sensitive to drugs attacking their waste disposal

September 4, 2013

By Oncology Nurse Advisor

Triple-negative breast cancers may be vulnerable to drugs that attack the proteasome.

Stress fuels cancer spread by triggering master gene

August 28, 2013

By Medical News Today

A new study from the US published in the Journal of Clinical Investigation finds that activation of a master gene called ATF3 that is important for helping cells adapt to stress may be involved in helping breast, and possibly other cancers spread to other parts of the body (metastasis).

New therapy strategy for breast cancer that has spread to the brain

August 26, 2013

By Oncology Nurse Advisor

Cellular therapy and gene therapy have been successfully combined in a mouse model to develop a viable treatment strategy for breast cancer that has spread to a patient's brain.

Fighting metastatic breast cancer one day, one week, one month at a time

August 23, 2013

By Houston chronicle Boomertown blog

Lori Sumako was your perfect, stage 1 breast cancer patient.

She followed all of her doctor’s orders. She endured the surgery and chemotherapy without (too many) complaints. She and husband Rick Mitchell gave thanks for each year that she was cancer-free.
Five years later, Sumako, a labor and delivery nurse, was told she was cured. A year after that, she started to believe it.

Chemoradiation Therapy for the Treatment of Bone Metastases

August 7, 2013

By Cancer Network

The combination of the chemotherapy capecitabine with external beam radiation was found to be both safe and effective in treating pain from bone metastases in patients with advanced breast cancer. The results from the small 29-patient phase II study are published in PLOS ONE.

Noted KU metastatic breast cancer researcher Danny Welch, PhD receives $225k grant for metastasis research

August 1, 2013

By Kansas City Kansan

KANSAS CITY, KAN. --- Susan G. Komen® today announced $4.5 million in research funding to more fully understand the role that environmental issues play in breast cancer development.

the frants include: $225,000 to Komen Scholar Danny Welch, M.D., for continuing studies into factors that lead to metastasis in breast cancer, and for specific investigations into why some individuals are more susceptible to developing breast cancer than others, and also the biology of two genes that suppress metastasis (KISS1 and the breast cancer suppressor-1,BRMS-1, gene).

Technique Filters Cancer Where Chemo Can't Reach

July 31, 2013

By Health News Digest

A cancer therapy that removes malignant cells from a patient's cerebrospinal fluid may soon be available to prevent metastases and decrease complications of cancers involving the brain, according to Penn State medical researchers.

Scientists Seek to Rein In Diagnoses of Cancer

July 30, 2013

By Tara Parker-Pope, New York Times

A group of experts advising the nation’s premier cancer research institution has recommended changing the definition of cancer and eliminating the word from some common diagnoses as part of sweeping changes in the nation’s approach to cancer detection and treatment.

The recommendations, from a working group of the National Cancer Institute, were published on Monday in The Journal of the American Medical Association. They say, for instance, that some premalignant conditions, like one that affects the breast called ductal carcinoma in situ, which many doctors agree is not cancer, should be renamed to exclude the word carcinoma so that patients are less frightened and less likely to seek what may be unneeded and potentially harmful treatments that can include the surgical removal of the breast.

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