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New models of drug-resistant breast cancer hint at better treatments

October 21, 2013

By Genome Institute of Washington University

Researchers at The Genome Institute and Washington University School of Medicine have shown that human breast tumors transplanted into mice are excellent models of metastatic cancer and could be valuable tools in the search for better treatments.

UM researchers take new view in understanding metastatic breast cancer

October 21, 2013

By Scott Dance, Baltimore Sun

Focus on 'microtentacles' aims to prevent disease's ability to spread

Breast cancer kills when rogue tumor cells spread through the bloodstream, squeezing through microscopic gaps to inundate organs until they fail. But what if that spread could be prevented, the cells left free-floating to be crushed in capillaries or to self-destruct instead?

A team of researchers at the University of Maryland School of Medicine, joined by entrepreneurs and other academics, has been exploring that question for nearly a decade. What they have found challenges the basis for most breast cancer research and treatment, which focus on preventing tumor cells from multiplying.

Rugo Offers Window Into Evolving Views of ER-Positive Disease

October 15, 2013

By Onc Live

Research efforts are under way to improve the efficacy of hormone therapy in the management of advanced estrogen receptor-positive (ER) breast cancer, including new strategies for targeting the PI3K/ mTOR pathway.

First Generic Version of Capecitabine Gains FDA Approval

October 14, 2013

By OncLive

The FDA has approved the first generic formulation of capecitabine (Xeloda), an oral chemotherapeutic that is currently approved to treat patients with metastatic colorectal cancer (mCRC) and metastatic breast cancer (MBC).

A roundup of FDA oncology news from September 2013

October 5, 2013

By Oncology Nurse Advisor

After winning accelerated approval from the U.S. FDA (FDA), Perjeta (pertuzumab) has become the first FDA-approved drug for the neoadjuvant treatment of breast cancer. The recombinant humanized monoclonal antibody was first approved in 2012 for the treatment of metastatic HER2-positive breast cancer.

Breast cancer spread: clues found in molecular switch

October 1, 2013

By Medical News Today

We have pinpointed the binding site that can cause increased spreading of breast cancer cells and thus the development of metastases.

Genentech’s Kadcyla Helped People With Advanced HER2-Positive Breast Cancer Live Longer Without Their Disease Worsening in New P

September 27, 2013

By Genentech

Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced that Kadcyla® (ado-trastuzumab emtansine) significantly extended the time people with advanced HER2-positive breast cancer (metastatic and unresectable locally advanced/recurrent) lived without their disease worsening (progression-free survival [PFS], a co-primary endpoint) compared to people who received a treatment of their physician’s choice in an open-label Phase III study called TH3RESA.

New knowledge on molecular mechanisms behind breast cancer

September 26, 2013

Researchers at University of Copenhagen have gained more insight into the molecular mechanisms of importance for, for example, cancer cell growth and metastasis.

Metastatic breast cancer - 'it's like getting all four tires flattened'

September 19, 2013

By Claudia Feldman, Houston Chronicle

Lori's complete story: Parts 1 and 2

Lori Sumako was your perfect, stage 1 breast cancer patient.

She followed all of her doctor's orders. She endured the surgery and chemotherapy without (too many) complaints. She and husband Rick Mitchell gave thanks for each year that she was cancer-free.

FDA approves Teva's generic version of Roche cancer drug Xeloda

September 18, 2013

The US Food and Drug Administration said it approved Teva Pharmaceutical Industries Ltd's generic version of Roche Holding AG's cancer drug Xeloda.

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